ATP attenuates olaparib-induced gastric damage in rats
Mesud Fakirullahoglu, Ayetullah Temiz, Mustafa Yeni, Esra Tuba Sezgin, Gulce Naz Yazici, Durdu Altuner, Mine Gulaboglu, Halis Suleyman · 2026
Read ATP attenuates olaparib-induced gastric damage in rats by Mesud Fakirullahoglu, Ayetullah Temiz, Mustafa Yeni, Esra Tuba Sezgin, Gulce Naz Yazici, Durdu Altuner, Mine Gulaboglu, Halis Suleyman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13334125.txt.
Description
Mesud Fakirullahoglu and co-authors tested whether adenosine triphosphate can protect the stomach against damage from the cancer drug olaparib, in a 2026 rat study. Olaparib, a PARP inhibitor, causes gastrointestinal side effects that oxidative stress may help explain.
Rats were split into healthy control, olaparib-only, ATP-only, and combined groups. Stomach injury was scored by ulcer area and count, tissue slides were examined, and lipid peroxidation plus antioxidant defenses were measured. Olaparib alone produced marked mucosal injury, heavy tissue damage, and strong oxidative stress. Adding ATP shrank ulcers, preserved tissue structure, and restored oxidative balance across the measures taken. The findings suggest a simple energy molecule might shield the stomach during PARP inhibitor therapy, pending further work.
Catalog record
| CREATOR | Mesud Fakirullahoglu, Ayetullah Temiz, Mustafa Yeni, Esra Tuba Sezgin, Gulce Naz Yazici, Durdu Altuner, Mine Gulaboglu, Halis Suleyman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33089 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |