Diagnostic utility of basal luteinizing hormone in evaluating central precocious puberty
Vittorio Ferrari, Daniela Elleri, Jennifer Roach, Mike Crane, Rod Thomas Mitchell · 2026
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Description
Vittorio Ferrari and co-authors tested whether a single basal blood measurement can stand in for stimulation testing in suspected early puberty, in a 2026 diagnostic study. The GnRH stimulation test is the standard check but is slow and costly.
The team reanalyzed 258 first-time GnRH tests done for suspected central precocious puberty at Edinburgh's Royal Hospital for Children and Young People between 2011 and 2025. Morning basal luteinizing hormone was measured just before testing, with special handling for values below assay detection limits. Basal hormone predicted a pubertal test response with an area under the curve of 0.80 in the analysis. A threshold of 0.5 units per liter balanced sensitivity and specificity, while values at or above 1.0 were always right. Such cutoffs could spare many children the full test.
Catalog record
| CREATOR | Vittorio Ferrari, Daniela Elleri, Jennifer Roach, Mike Crane, Rod Thomas Mitchell |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33058 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |