HBV pgRNA induces chronic inflammation in an IL-1β-dependent manner
Aikaterini Skeva, Konstantinos Marmanis, Maria Ntinopoulou, Panagiotis Liakopoulos, Eleni Tryfonopoulou, Anna Chalkidou, Stella Arelaki, Katerina Chlichlia, Maria Koffa, Akrivi Chrysanthopoulou, Petros Kolovos, Alexandra Giatromanolaki, Konstantinos Mimidis, Theocharis G. Konstantinidis, Maria Panopoulou · 2026
Read HBV pgRNA induces chronic inflammation in an IL-1β-dependent manner by Aikaterini Skeva, Konstantinos Marmanis, Maria Ntinopoulou, Panagiotis Liakopoulos, Eleni Tryfonopoulou, Anna Chalkidou, Stella Arelaki, Katerina Chlichlia, Maria Koffa, Akrivi Chrysanthopoulou, Petros Kolovos, Alexandra Giatromanolaki, Konstantinos Mimidis, Theocharis G. Konstantinidis, Maria Panopoulou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13333505.txt.
Description
Aikaterini Skeva and a Greek team report in 2026 that a fragment of hepatitis B virus genetic material circulating in blood does more than mark viral activity: it stirs inflammation. Pregenomic RNA can be detected in patients on treatment, and the study asked what immune machinery its presence switches on.
Among 88 chronic hepatitis B patients, 18.1 percent carried pregenomic RNA. Gene profiling of eight patients, half positive and half negative, converged on platelet activation and neutrophil granule-release pathways. Lab work showed platelets exposed to positive serum switched on self-digesting autophagy and freshly made the germ-fighting peptide LL-37. When platelets met neutrophils, the pair adopted an inflammatory stance heavy on IL-1β with little net formation. The same IL-1β and LL-37 excess showed up in patient liver tissue. The authors conclude the viral RNA drives a platelet-neutrophil inflammatory axis, offering an angle on why hepatitis B smoulders even under therapy.
Catalog record
| CREATOR | Aikaterini Skeva, Konstantinos Marmanis, Maria Ntinopoulou, Panagiotis Liakopoulos, Eleni Tryfonopoulou, Anna Chalkidou, Stella Arelaki, Katerina Chlichlia, Maria Koffa, Akrivi Chrysanthopoulou, Petros Kolovos, Alexandra Giatromanolaki, Konstantinos Mimidis, Theocharis G. Konstantinidis, Maria Panopoulou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50767 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |