Impact of early life stress on the immune response and bone regeneration after fracture
Dorothea Gebauer, Tamara Schimmele, Dominik Langgartner, Jana Bleher, Anita Ignatius, Stefan O. Reber, Melanie Haffner-Luntzer · 2026
Read Impact of early life stress on the immune response and bone regeneration after fracture by Dorothea Gebauer, Tamara Schimmele, Dominik Langgartner, Jana Bleher, Anita Ignatius, Stefan O. Reber, Melanie Haffner-Luntzer (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13333303.txt.
Description
Dorothea Gebauer and co-authors tested whether stress in early life changes how the body answers a broken bone, in a 2026 mouse study. Early-life stress burdens about 39 percent of people and raises later bone disorder risk, yet its effect on fracture healing had never been examined.
Their two-hit model separated mouse pups from their mothers to mimic early stress, then gave adults a standardized thigh bone cut fixed with an external frame, alongside behavior tests and healing measures. Three hours after the break, stressed mice showed a damped inflammatory response, with several pro- and anti-inflammatory signals significantly reduced, an effect stronger in males. By days 10 and 21, however, healing measures no longer differed between stressed and control animals. The authors conclude early stress reshapes the first immune reaction to fracture in a sex-dependent way without derailing the repair itself.
Catalog record
| CREATOR | Dorothea Gebauer, Tamara Schimmele, Dominik Langgartner, Jana Bleher, Anita Ignatius, Stefan O. Reber, Melanie Haffner-Luntzer |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45582 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |