Response to the Letter to the Editor Entitled “Diagnostic Latency and Unmeasured Disease Severity In Male Lupus Nephritis”
Kristina K Nasr, Ryan B Coopergard, Sisi Ma, Tak Mao Chan, Manish Rathi, Frederic A Houssiau, Zdenka Hruskova, Vivekanand Jha, Neil Solomons, Stephen M Korbet, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Vladimir Tesar, Matt Truman, Juan Mejia-Vilet, Melissa R West, Brad H Rovin, Patrick H Nachman · 2026
Read Response to the Letter to the Editor Entitled “Diagnostic Latency and Unmeasured Disease Severity In Male Lupus Nephritis” by Kristina K Nasr, Ryan B Coopergard, Sisi Ma, Tak Mao Chan, Manish Rathi, Frederic A Houssiau, Zdenka Hruskova, Vivekanand Jha, Neil Solomons, Stephen M Korbet, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Vladimir Tesar, Matt Truman, Juan Mejia-Vilet, Melissa R West, Brad H Rovin, Patrick H Nachman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13333287.txt.
Description
Kristina Nasr and co-authors publish in 2026 a reply to a letter questioning their study of sex differences in lupus nephritis. Their original work, on a large international patient group, found men arriving with worse kidney function than women. The letter writer suggested men's disease may simply be found later, since doctors suspect lupus less in men, so the gap could reflect delay rather than severity.
The authors thank the critic and concede the point's plausibility: late detection in men is possible, and baseline readings could hide scarring that classifications miss. They note the timing of autoimmune disease onset is intrinsically hard to pin down, since early symptoms are vague. A prospective study with systematic testing could settle the matter, they agree, while noting such studies are rarely fundable. The exchange is a model of the genre: a limitation named, partly absorbed, and converted into a research agenda.
Catalog record
| CREATOR | Kristina K Nasr, Ryan B Coopergard, Sisi Ma, Tak Mao Chan, Manish Rathi, Frederic A Houssiau, Zdenka Hruskova, Vivekanand Jha, Neil Solomons, Stephen M Korbet, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Vladimir Tesar, Matt Truman, Juan Mejia-Vilet, Melissa R West, Brad H Rovin, Patrick H Nachman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 4 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |