Survival outcomes of radiotherapy alone versus concurrent chemoradiotherapy in T1–2 head and neck cancer with low-volume disease: A multicenter cohort study
Chuanhao Zhang, Zhichao Cheng, Xin Jiang, Genghao Zhao, Yanmei Zhu, Bowen Hou, Yingming Sun, Shanshan Liang, Ye Zhang, Ruoyu Wang, Zhe Wang · 2026
Read Survival outcomes of radiotherapy alone versus concurrent chemoradiotherapy in T1–2 head and neck cancer with low-volume disease: A multicenter cohort study by Chuanhao Zhang, Zhichao Cheng, Xin Jiang, Genghao Zhao, Yanmei Zhu, Bowen Hou, Yingming Sun, Shanshan Liang, Ye Zhang, Ruoyu Wang, Zhe Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13333277.txt.
Description
Chuanhao Zhang and colleagues compared radiation alone against radiation plus chemotherapy for early head and neck cancers with small lymph node spread, in a 2026 multicenter cohort study. Adding chemotherapy is standard for advanced disease but brings heavy toxicity, and whether small-volume cases need it was unsettled.
The study gathered 240 patients with stage T1–2, N1–2a squamous cancers from centers in China and Canada, with a median age of 57.8 years and 21 percent HPV-negative, and balanced the groups by treatment weighting. Combined treatment did not significantly improve overall survival, with a hazard ratio of 0.50 and wide uncertainty, but it did improve freedom from progression, with a hazard ratio of 0.42. The pattern matches the NRG-HN002 trial's drop in local failure. The authors advise weighing the control gain against toxicity case by case and call for larger prospective trials.
Catalog record
| CREATOR | Chuanhao Zhang, Zhichao Cheng, Xin Jiang, Genghao Zhao, Yanmei Zhu, Bowen Hou, Yingming Sun, Shanshan Liang, Ye Zhang, Ruoyu Wang, Zhe Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22411 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |