Sex-specific associations of perioperative Resolvin D1 and D2 dynamics with postoperative atrial fibrillation in cardiac surgery: a secondary analysis of a prospective observational study
Melina Heine, Felix Ulbrich, Samuel Justice, Babak Saravi, Simon A Amacher, Julian Hubrich, Leonard Simeth, Asishana Osho, Charles N Serhan, Jochen D Muehlschlegel, Jakob Wollborn · 2026
Read Sex-specific associations of perioperative Resolvin D1 and D2 dynamics with postoperative atrial fibrillation in cardiac surgery: a secondary analysis of a prospective observational study by Melina Heine, Felix Ulbrich, Samuel Justice, Babak Saravi, Simon A Amacher, Julian Hubrich, Leonard Simeth, Asishana Osho, Charles N Serhan, Jochen D Muehlschlegel, Jakob Wollborn (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13332794.txt.
Description
Melina Heine and colleagues examined inflammation-resolving molecules around heart surgery in a 2026 secondary analysis of a prospective study. Atrial fibrillation after surgery is common and tied to inflammation, but whether the body's active clean-up system, the specialized pro-resolving mediators, plays a part was unknown.
The cohort held 319 adults who had cardiac surgery at one center, with resolvin D1 and D2 measured across the operative period and modeled against later fibrillation. Patients who developed the rhythm problem showed higher predicted resolvin D1 levels, with a mean ratio of 1.19, and lower resolvin D2 at 0.80. The D1 link ran stronger in women than men, and women also tended toward a deeper D2 drop, though that pattern missed significance. The authors read the split pattern as a sign the two mediators do different jobs, and that resolution biology differs by sex.
Catalog record
| CREATOR | Melina Heine, Felix Ulbrich, Samuel Justice, Babak Saravi, Simon A Amacher, Julian Hubrich, Leonard Simeth, Asishana Osho, Charles N Serhan, Jochen D Muehlschlegel, Jakob Wollborn |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38971 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |