Antineutrophil Cytoplasmic Antibody (ANCA)-Positive Eosinophilic Granulomatosis With Polyangiitis Presenting With Refractory Asthma, Mononeuritis Multiplex, and Cutaneous Vasculitis: A Case Report
Khaled M Malkawi, James Beynon, Hitasha Rupani · 2026
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Description
Khaled M Malkawi and colleagues report a 2026 case of ANCA-positive eosinophilic granulomatosis with polyangiitis presenting as stubborn asthma plus nerve and skin disease. This rare small-vessel inflammation features asthma, high counts of a white cell type, and tissue inflammation rich in those cells. Early diagnosis is often hard because first signs mimic uncontrolled asthma or other eosinophilic lung diseases. The patient was a 66-year-old man with adult-onset asthma and four months of worsening breathlessness, general symptoms, nerve damage, and skin inflammation.
Tests showed markedly high eosinophil counts, raised inflammation markers, and high creatine kinase, lactate dehydrogenase, and IgG4. Imaging showed calcified chest lymph nodes without lung infiltrates. A key antibody test was positive, and skin biopsy confirmed small-vessel inflammation with eosinophil buildup. The case urges clinicians to weigh this disease when asthma resists care and nerve or skin signs join the picture.
Catalog record
| CREATOR | Khaled M Malkawi, James Beynon, Hitasha Rupani |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 17 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |