The ubiquitin-like protein FAT10 enhances the autophagy-mediated degradation of ZO-1 by stabilizing ATG3 to promote the lung metastasis of colon cancer
Zijing Li, Hengqing Zhu, Dongnian Du, Dandan Zhang, Xuzhe Yu, Fei Xie, Miao Ye, Qing Wang, Rong Wan, Jin Ge, Jianghua Shao · 2026
Read The ubiquitin-like protein FAT10 enhances the autophagy-mediated degradation of ZO-1 by stabilizing ATG3 to promote the lung metastasis of colon cancer by Zijing Li, Hengqing Zhu, Dongnian Du, Dandan Zhang, Xuzhe Yu, Fei Xie, Miao Ye, Qing Wang, Rong Wan, Jin Ge, Jianghua Shao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13332105.txt.
Description
Zijing Li, Hengqing Zhu, Dongnian Du, and eight colleagues uncover a spread pathway in colon cancer in this two thousand twenty-six paper. FAT10 is a ubiquitin-like protein that normally routes substrates to the proteasome; its role in autophagy-based breakdown was unclear. The team measured FAT10 in colon cancer tissues and cells, finding it raised, and used cell and animal tests to check its effect on invasion and spread. Mass spectrometry identified its binding partners.
Extra FAT10 enhanced cancer cell invasion and spread. In mechanism, FAT10 stabilizes the autophagy protein ATG3 by competing with ubiquitin for binding, switching autophagy on. The activated autophagy then degrades ZO-1, a key tight-junction protein, loosening cells for migration. An ATG3 blocker reversed the ZO-1 loss and suppressed lung spread. The authors present the FAT10-ATG3-autophagy axis as a new therapy target in colon cancer.
Catalog record
| CREATOR | Zijing Li, Hengqing Zhu, Dongnian Du, Dandan Zhang, Xuzhe Yu, Fei Xie, Miao Ye, Qing Wang, Rong Wan, Jin Ge, Jianghua Shao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |