Functional immune profiling reveals CD4 + T cell dysregulation in coeliac disease
Anthony J Farchione, HoChan Cheon, David Vremec, Julika Neumann, Gwenny M Verstappen, Melinda Y Hardy, Mai B Margetts, Lauren J Howson, Lee M Henneken, Maureen Forde, Jason A Tye‐Din, Susanne Heinzel, Philip D Hodgkin, Vanessa L Bryant · 2026
Read Functional immune profiling reveals CD4 + T cell dysregulation in coeliac disease by Anthony J Farchione, HoChan Cheon, David Vremec, Julika Neumann, Gwenny M Verstappen, Melinda Y Hardy, Mai B Margetts, Lauren J Howson, Lee M Henneken, Maureen Forde, Jason A Tye‐Din, Susanne Heinzel, Philip D Hodgkin, Vanessa L Bryant (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13331542.txt.
Description
Anthony Farchione, Jason Tye-Din, and a large team probed immune cells in coeliac disease, in work from twenty twenty-six. In that disease, gluten sets off an immune attack on the gut. Genes raise the risk, but how risk turns into faulty cells was not clear. The team built a new test that wakes T cells in a set way, then stops the signal and clocks their growth and survival.
Cells from patients, above all the CD4 kind, grew weakly and made less of a key growth signal. They also died off more and stayed switched on too long. These traits showed in new cases and in patients on a gluten-free diet alike. The team sees a built-in fault, not just a flare.
Catalog record
| CREATOR | Anthony J Farchione, HoChan Cheon, David Vremec, Julika Neumann, Gwenny M Verstappen, Melinda Y Hardy, Mai B Margetts, Lauren J Howson, Lee M Henneken, Maureen Forde, Jason A Tye‐Din, Susanne Heinzel, Philip D Hodgkin, Vanessa L Bryant |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |