Reperfusion injury from a haemodynamic standpoint and role of pressure-controlled reperfusion in avoiding reperfusion injury
Murat Sezer, Ahmet Tas, Yaren Alan, Ilke Kara Tas, Alp Ozcan, Divaka Perera, Irem Sezer, Sayan Sen, Jan J Piek, Sabahattin Umman · 2026
Read Reperfusion injury from a haemodynamic standpoint and role of pressure-controlled reperfusion in avoiding reperfusion injury by Murat Sezer, Ahmet Tas, Yaren Alan, Ilke Kara Tas, Alp Ozcan, Divaka Perera, Irem Sezer, Sayan Sen, Jan J Piek, Sabahattin Umman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13331139.txt.
Description
Murat Sezer and team recast reperfusion injury from a blood-flow standpoint. Their 2026 review notes no set treatment exists for post-blockage reperfusion injury, which oddly worsens microvascular and tissue damage in any reperfused area. During the blockage, the body's pressure control briefly fails through increased oxygen demand and blockage damage. It leaves the injured distal capillary bed open against the sudden unchecked pressure rise when blood returns.
The team recasts it as a capillary hyperpressurization syndrome, set by initial reperfusion pressure. Acute vessel barotrauma from abrupt full-pressure reperfusion triggers later damage. So starting it gently at lower pressure, termed pressure-controlled reperfusion, and holding it until natural muscle control returns may limit growing damage. The same disease process, acute contact of injured vessel lining with an unchecked pressure rise, appears to dictate post-reperfusion damage in the heart and other organs, where gentle-pressure methods may help.
Catalog record
| CREATOR | Murat Sezer, Ahmet Tas, Yaren Alan, Ilke Kara Tas, Alp Ozcan, Divaka Perera, Irem Sezer, Sayan Sen, Jan J Piek, Sabahattin Umman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |