Synthesis and structure of 5,5′-(trisulfane-1,3-diyl)bis(1,3,4-thiadiazol-2-amine)
Aziz Atashov, Batirbay Torambetov, Jamshid Ashurov, Tuncer Hökelek, Alebel N. Belay, Asmet N. Azizova · 2026
Read Synthesis and structure of 5,5′-(trisulfane-1,3-diyl)bis(1,3,4-thiadiazol-2-amine) by Aziz Atashov, Batirbay Torambetov, Jamshid Ashurov, Tuncer Hökelek, Alebel N. Belay, Asmet N. Azizova (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13330805.txt.
Description
Aziz Atashov and team present the making and structure of a trisulfane-bridged bis-thiadiazole. Their 2026 structure paper covers 5,5'-(trisulfane-1,3-diyl)bis(1,3,4-thiadiazol-2-amine), with two thiadiazol-2-amine moieties bridged by a trisulfanediyl group. The 1,3,4-thiadiazole ring has five members, with two nitrogen atoms and one sulfur atom, valued as a stable, electron-poor scaffold for diverse bioactive compounds.
In the crystal, N-H···N bonds form endless chains along [010]. Groups at the 2- and 5-positions of these rings enable creation of germ-fighting and cancer-fighting leads. Common routes include ring-closing of thiosemicarbazides or diacylhydrazines, substitution, and C-H activation. The paper covers the new compound by spectroscopy and refinement, with hydrogen spots set by a riding model. The report adds a trisulfane-bridged example to this ring family, backing further work on sulfur-bridged rings in bioactive design.
Catalog record
| CREATOR | Aziz Atashov, Batirbay Torambetov, Jamshid Ashurov, Tuncer Hökelek, Alebel N. Belay, Asmet N. Azizova |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 6 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |