Genomic landscape and fine-scale population structure of Helicobacter pylori across China
Yi Dou, Pengfei Kong, Mingzhu Huang, Yonghu Xu, Jingyu Guo, Yong Xie, Xiaohua Jiang, Yantao Duan, Gonghong Wei, Dazhi Xu · 2026
Read Genomic landscape and fine-scale population structure of Helicobacter pylori across China by Yi Dou, Pengfei Kong, Mingzhu Huang, Yonghu Xu, Jingyu Guo, Yong Xie, Xiaohua Jiang, Yantao Duan, Gonghong Wei, Dazhi Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13330326.txt.
Description
Yi Dou and co-authors map the genomes of Helicobacter pylori, a stomach bacterium tied to gastric cancer, across China. Published in 2026, the study analyzed whole genomes from 1,243 isolates gathered in 20 provinces and regions, including 50 new strains from Shanghai. East Asian strains are usually lumped into one lineage said to be highly virulent.
That single label hid real structure: six geographically shaped subpopulations emerged. One was spread widely on the mainland, while groups from Inner Mongolia and Taiwan diverged most. Virulence gene sets and predicted drug resistance also varied sharply by subtype. In Taiwan one single mutation drove a very high rate of resistance to one antibiotic. Lab tests backed the mutation based predictions.
Catalog record
| CREATOR | Yi Dou, Pengfei Kong, Mingzhu Huang, Yonghu Xu, Jingyu Guo, Yong Xie, Xiaohua Jiang, Yantao Duan, Gonghong Wei, Dazhi Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |