The dual balance of the cytokine network: key messengers of immune activation and triggers of cytokine storm
Yixiao Zhang, Dezhi Guo, Yuanhang Zhou, Changli Wang, Guowei Su, Jie Huang, Yiwen Wan, Haoling Zhang, Haifang Wan, Lulong Bo, Wangzheqi Zhang · 2026
Read The dual balance of the cytokine network: key messengers of immune activation and triggers of cytokine storm by Yixiao Zhang, Dezhi Guo, Yuanhang Zhou, Changli Wang, Guowei Su, Jie Huang, Yiwen Wan, Haoling Zhang, Haifang Wan, Lulong Bo, Wangzheqi Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13330234.txt.
Description
Yixiao Zhang and co-authors review the balance of immune messenger proteins in health and disease in a 2026 article. Cytokines that drive swelling and those that calm it must stay in dynamic balance for immune replies to stay apt. Feedback loops tune the strength and length of each reply.
When balance breaks, swelling signals can cascade, calm signals can fall short, and gene control can warp. The review links such breaks to sepsis, psoriasis, joint and bowel disease, and cancer, shaped by infection, autoimmunity, and tumour settings. Care options covered include antibody drugs, Janus kinase blockers, dual-target antibodies, and cell therapy. Gains, risks, and next steps are weighed for precision immune care.
Catalog record
| CREATOR | Yixiao Zhang, Dezhi Guo, Yuanhang Zhou, Changli Wang, Guowei Su, Jie Huang, Yiwen Wan, Haoling Zhang, Haifang Wan, Lulong Bo, Wangzheqi Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 170013 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |