Comparative efficacy and safety of olezarsen versus volanesorsen for familial chylomicronemia syndrome: a matching-adjusted indirect comparison
Handrean Soran, Asia Sikora Kessler, Montserrat Vera-Llonch, Veronica J Alexander, Paul Serafini, Divya Pushkarna, Elisabete Rodrigues, Erik Stroes, Ulrike Schatz, Ursula Kassner, Zalmai Hakimi, Aletta Falk, Koo Wilson · 2026
Read Comparative efficacy and safety of olezarsen versus volanesorsen for familial chylomicronemia syndrome: a matching-adjusted indirect comparison by Handrean Soran, Asia Sikora Kessler, Montserrat Vera-Llonch, Veronica J Alexander, Paul Serafini, Divya Pushkarna, Elisabete Rodrigues, Erik Stroes, Ulrike Schatz, Ursula Kassner, Zalmai Hakimi, Aletta Falk, Koo Wilson (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13329855.txt.
Description
Handrean Soran and a large team compare two targeted drugs for a rare fat disorder in a 2026 indirect analysis. Familial chylomicronemia syndrome causes very high triglycerides and repeat pancreas attacks, and standard fat-lowering drugs fail since a key enzyme is missing. Both olezarsen and volanesorsen block apolipoprotein C-III.
Patient data for olezarsen came from the Balance trial with 45 people, weighted to match the APPROACH trial group of 66 people on volanesorsen. At 52 weeks, gaps in fat and target protein change favoured olezarsen in point values, yet none reached statistical clarity in the reported ranges. Pancreas attack and harm risks also showed no clear gaps. The work gives context where direct trials are absent.
Catalog record
| CREATOR | Handrean Soran, Asia Sikora Kessler, Montserrat Vera-Llonch, Veronica J Alexander, Paul Serafini, Divya Pushkarna, Elisabete Rodrigues, Erik Stroes, Ulrike Schatz, Ursula Kassner, Zalmai Hakimi, Aletta Falk, Koo Wilson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39754 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |