Ondansetron exhibits potent antiviral activity against enterovirus 71 infection in vitro and in vivo
Zhenyang Li, Jianqiao Rui, Jiazheng Li, Sichen Ren, Yan Luo, Weiyan Zhu, Huimin Tao, Mingzhu Guo, Qingsong Dai, Wan Peng, Siqi Li, Xiaojia Guo, Wei Li, Jingjing Yang, Ruiyuan Cao, Wu Zhong · 2026
Read Ondansetron exhibits potent antiviral activity against enterovirus 71 infection in vitro and in vivo by Zhenyang Li, Jianqiao Rui, Jiazheng Li, Sichen Ren, Yan Luo, Weiyan Zhu, Huimin Tao, Mingzhu Guo, Qingsong Dai, Wan Peng, Siqi Li, Xiaojia Guo, Wei Li, Jingjing Yang, Ruiyuan Cao, Wu Zhong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13329555.txt.
Description
Zhenyang Li and a large team report in 2026 that ondansetron, a drug used against nausea, also fights enterovirus A71. That virus causes hand, foot, and mouth disease and can harm the brain and heart in severe child cases. No approved virus-specific drug exists for it, so the team screened for new options.
Tests in cells and in living models showed strong action against the virus, the authors report. The drug acted early, at the steps where the virus attaches to and enters cells. Genes tied to cholesterol handling, including ABCA1, ABCG1, and HMGCS1, changed with treatment. The authors propose targeting host fat balance as a fresh antiviral strategy worth further study.
Catalog record
| CREATOR | Zhenyang Li, Jianqiao Rui, Jiazheng Li, Sichen Ren, Yan Luo, Weiyan Zhu, Huimin Tao, Mingzhu Guo, Qingsong Dai, Wan Peng, Siqi Li, Xiaojia Guo, Wei Li, Jingjing Yang, Ruiyuan Cao, Wu Zhong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39544 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |