Surrogate virus neutralization test as a scalable and reliable tool for immune surveillance in booster-vaccinated populations
Lin Cai, Zhaoyang Fang, Renyun Zha, Zhifeng Zhou, Ruiyin Zhang, Xueyun Li, Cheng Guo, Conghui Liao · 2026
Read Surrogate virus neutralization test as a scalable and reliable tool for immune surveillance in booster-vaccinated populations by Lin Cai, Zhaoyang Fang, Renyun Zha, Zhifeng Zhou, Ruiyin Zhang, Xueyun Li, Cheng Guo, Conghui Liao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13328727.txt.
Description
Lin Cai and co-authors validate a fast surrogate test for tracking COVID immunity after booster shots, in a 2026 study. Vaccine protection wanes and variants keep slipping past antibodies, so health systems need cheap ways to watch population immunity. True neutralization tests are slow and need live-virus labs; a surrogate test mimics the key blocking step in a plate.
Sera from 259 people after a third inactivated dose were tested by the surrogate and by a pseudovirus standard, plus binding antibody assays. A second cohort of 288 gave paired samples around a booster. Agreement between the methods shows whether the surrogate can stand in at scale. A trustworthy shortcut lets officials time booster campaigns with data, not guesses.
Catalog record
| CREATOR | Lin Cai, Zhaoyang Fang, Renyun Zha, Zhifeng Zhou, Ruiyin Zhang, Xueyun Li, Cheng Guo, Conghui Liao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |