Oral yeast-displayed SARS-CoV-2 spike protein vaccine enhanced by trimerization and flagellin peptide
Tahereh Saveii, Sareh Arjmand, Ismaeil Haririan, Navid Pourzardosht, Reza H Sajedi · 2026
Read Oral yeast-displayed SARS-CoV-2 spike protein vaccine enhanced by trimerization and flagellin peptide by Tahereh Saveii, Sareh Arjmand, Ismaeil Haririan, Navid Pourzardosht, Reza H Sajedi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13328625.txt.
Description
Tahereh Saveii and co-authors test a mouth-given vaccine idea in this 2026 study. They used yeast as a tiny display stand, mounting the binding tip of the SARS-CoV-2 spike protein on the yeast surface. Oral vaccines are easier to give and store than shots, and they can stir defenses in the gut as well as the blood.
The team built three yeast versions. One added a folding piece that groups the protein in threes; another also added a bacterial fragment that wakes up the immune system. Checks with imaging and lab tests confirmed the proteins sat correctly on the yeast. Mice fed the yeast made antibodies in blood and gut samples. The third version, with both extras, drew the strongest response, which the authors call a promising path for future vaccines.
Catalog record
| CREATOR | Tahereh Saveii, Sareh Arjmand, Ismaeil Haririan, Navid Pourzardosht, Reza H Sajedi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |