Ershiwuwei Shanhu Pill ameliorates cognitive impairment in Alzheimer’s disease mice by remodeling gut microbiota and host serum metabolites
Ning Li, Kunxia Jiang, Xiaoyuan Peng, Ce Yang, Wei Xiong, Wenxiang Wang · 2026
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Description
Ning Li and co-authors test a Tibetan pill in Alzheimer's model mice in a 2026 study. Ershiwuwei Shanhu Pill is used in Tibetan practice for dementia, and the team asked whether it works through gut microbes and blood chemistry. Transgenic mice received 200 mg/kg by mouth daily for two months, eleven per group.
Treated mice performed better in a water maze, carried less amyloid and phosphorylated tau in the brain, and showed calmer brain inflammation. Gut profiling found more Dubosiella and less Bacteroides, while blood metabolites shifted in tryptophan and sugar pathways, including higher fructose 1,6-bisphosphate. A gut-metabolite-brain route may carry the pill's protection, the authors propose.
Catalog record
| CREATOR | Ning Li, Kunxia Jiang, Xiaoyuan Peng, Ce Yang, Wei Xiong, Wenxiang Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48779 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |