Behind the scenes of a 7T MRI clinical study in Alzheimer's disease: challenges and recommendations for future research
Maria Dobrushina, Friedrich Krohn, Sayyeda Chandni, Linda Dietrich, Wenzel Glanz, Michaela Butryn, Dorothea Hämmerer, Lucía Penalba-Sánchez · 2026
Read Behind the scenes of a 7T MRI clinical study in Alzheimer's disease: challenges and recommendations for future research by Maria Dobrushina, Friedrich Krohn, Sayyeda Chandni, Linda Dietrich, Wenzel Glanz, Michaela Butryn, Dorothea Hämmerer, Lucía Penalba-Sánchez (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13328257.txt.
Description
Maria Dobrushina and co-authors share early lessons from a 7-tesla MRI drug study in Alzheimer's disease in a 2026 perspective. Pairing medicines with ultra-high-field imaging promises sharp data, but the practical hurdles of the early phases are seldom reported. Their pool began with 1,001 patients at their site.
Only 476 carried the needed diagnosis of mild cognitive impairment or mild dementia from Alzheimer's, and just 48 people, 10 percent of that group, passed every screen. Beta-blocker use alone excluded 27.5 percent at one stage, lack of interest took 20 percent, and metal or tattoos barred 8 percent in the tallies given. The authors offer fixes for recruiting, screening, and scheduling that balance strict science with real-world feasibility.
Catalog record
| CREATOR | Maria Dobrushina, Friedrich Krohn, Sayyeda Chandni, Linda Dietrich, Wenzel Glanz, Michaela Butryn, Dorothea Hämmerer, Lucía Penalba-Sánchez |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18679 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |