CD109 exhibits a dynamic expression pattern in coronary endothelium and endocardial-derived valve mesenchyme during heart development with preserved morphogenesis following endothelial-specific deletion
Andrew B. Harvey, Jenna R. Drummond, Hannah G. Tarolli, Renélyn A. Wolters, Raymond N. Deepe, Inara Devji, Jeremy L. Barth, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels · 2026
Read CD109 exhibits a dynamic expression pattern in coronary endothelium and endocardial-derived valve mesenchyme during heart development with preserved morphogenesis following endothelial-specific deletion by Andrew B. Harvey, Jenna R. Drummond, Hannah G. Tarolli, Renélyn A. Wolters, Raymond N. Deepe, Inara Devji, Jeremy L. Barth, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13328117.txt.
Description
Andrew B Harvey and a large team chart a signaling protein in the developing heart in a 2026 study. CD109, a surface protein that tunes TGF-β signals, has surfaced in genome scans for coronary disease and in patients with congenital heart defects, yet its developmental role was unstudied. The team mapped its presence in mouse hearts and deleted it from vessel lining cells.
Cd109 showed strongly in coronary vessel lining and in valve tissue derived from the heart's inner lining, persisting across key stages. Silencing it in human lining cells disturbed vessel growth programs and tube building. Mice lacking it in those cells still formed hearts without overt flaws. Backup systems may cover its loss during development, the results suggest.
Catalog record
| CREATOR | Andrew B. Harvey, Jenna R. Drummond, Hannah G. Tarolli, Renélyn A. Wolters, Raymond N. Deepe, Inara Devji, Jeremy L. Barth, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53325 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |