BOLD-based cerebrovascular reactivity is influenced by baseline cerebral blood volume and oxygen metabolism in humans
Gabriel Hoffmann, Lena Schmitzer, Jan Kufer, Matthias JP van Osch, Lena Václavů, Jan Kirschke, Christian Sorg, Stephan Kaczmarz, Christine Preibisch · 2026
Read BOLD-based cerebrovascular reactivity is influenced by baseline cerebral blood volume and oxygen metabolism in humans by Gabriel Hoffmann, Lena Schmitzer, Jan Kufer, Matthias JP van Osch, Lena Václavů, Jan Kirschke, Christian Sorg, Stephan Kaczmarz, Christine Preibisch (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13328114.txt.
Description
Gabriel Hoffmann and team showed that a brain vessel measure is skewed by starting blood volume. Their 2026 study set blood oxygen MRI vessel response, usually read during high carbon dioxide breathing, against direct brain blood flow response from arterial spin labelling. Data from fifty people at 3 Tesla held both response measures plus relative blood volume and oxygen uptake, plus dynamic simulations.
Grey and white matter differed sharply in blood oxygen response, while blood flow response was much the same across tissues. Between-person and within-person checks showed the grey-white gap in blood oxygen response mostly mirrors blood volume gaps, not artery travel time or starting blood flow. Simulations also pointed to a slow fall in oxygen use during high carbon dioxide breathing. The team holds that blood oxygen response leans hard on blood volume, a link that matters for vessel disease or tumor studies where blood volume shifts.
Catalog record
| CREATOR | Gabriel Hoffmann, Lena Schmitzer, Jan Kufer, Matthias JP van Osch, Lena Václavů, Jan Kirschke, Christian Sorg, Stephan Kaczmarz, Christine Preibisch |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |