The alveolar edema equation
John C. Grotberg, Francesco Romanò, James B. Grotberg · 2026
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Description
John C Grotberg, Francesco Romanò, and James B Grotberg build a fluid equation for lung edema in a 2026 modeling study. Fluid flooding the air sacs blocks gas exchange, and how cleared fluid reaches the lymph channels had puzzled physiologists since 1896. Their two-dimensional model of a tissue strip joins blood flow, tissue flow, and the air-side liquid layer.
About 80 percent of the strip carries straight cross-flow, letting them write simple pressure and flow formulas that clinicians can use. Against textbook habit, the air-side membrane's leakiness, not the capillary's, sets the cross-flow rate. Their edema equation for the blood pressure that triggers flooding matches clinical data and could tailor breathing support pressures.
Catalog record
| CREATOR | John C. Grotberg, Francesco Romanò, James B. Grotberg |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20879 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |