Contemporary review of primary membranous nephropathy

Edward J. Filippone, John L. Farber · 2026

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Description

Edward J Filippone and John L Farber give a contemporary review of primary membranous nephropathy in a 2026 article. The kidney disease is an autoimmune attack on podocyte targets, most often the PLA2R receptor. Fourteen other targets are now known, and the culprit stays hidden in 5 to 10 percent of cases. It usually appears as nephrotic syndrome.

About a third of patients remit on their own, a third head toward kidney failure, and the rest keep leaking protein, so treatment follows risk level. Low-risk patients can be watched, the highest-risk receive alternating steroids and cyclophosphamide, and mid-to-high-risk patients get rituximab with a 60 to 80 percent response expected on their summary. Antibody levels guide follow-up and flag relapse.

Catalog record

CREATOREdward J. Filippone, John L. Farber
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE100478
LICENSEhttps://creativecommons.org/licenses/by/4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/article/MED/PMC13327930

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