Propofol attenuates pain hypersensitivity and neuroinflammation in chronic constriction injury rats by regulating miR-1249-3p/VEGFA axis
Hailin Zhao, Chuping Peng, Xiumei Zhu, Long Wang, Lu Ye · 2026
Read Propofol attenuates pain hypersensitivity and neuroinflammation in chronic constriction injury rats by regulating miR-1249-3p/VEGFA axis by Hailin Zhao, Chuping Peng, Xiumei Zhu, Long Wang, Lu Ye (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13327912.txt.
Description
Hailin Zhao and co-authors trace how propofol eases nerve pain in rats in a 2026 study. Chronic constriction injury of a nerve models lasting neuropathic pain, a condition with few good treatments. The team tested whether the anesthetic propofol works through a small RNA and its target gene, VEGFA.
Injured rats showed less miR-1249-3p and more VEGFA in the spinal cord, and reporter tests confirmed the RNA targets that gene. Seven days of propofol at 15 mg/kg lifted the RNA, lowered VEGFA, eased pain responses, and cut inflammatory markers, while blocking the RNA erased those gains unless VEGFA was also silenced. The chain runs through the NF-κB pathway, the authors report.
Catalog record
| CREATOR | Hailin Zhao, Chuping Peng, Xiumei Zhu, Long Wang, Lu Ye |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54545 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |