SARS‐CoV‐2 enhances lysosomal exocytosis and deacidifies lysosomes to facilitate viral release
Fujun Qin, Chuang Yan, Zizheng Liu, Dianbing Wang, Huimin Zhong, Qiang Ding, Minghai Chen, Xian‐En Zhang · 2026
Read SARS‐CoV‐2 enhances lysosomal exocytosis and deacidifies lysosomes to facilitate viral release by Fujun Qin, Chuang Yan, Zizheng Liu, Dianbing Wang, Huimin Zhong, Qiang Ding, Minghai Chen, Xian‐En Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13327611.txt.
Description
Fujun Qin and co-authors show how the COVID-19 virus uses cell recycling sacs to escape in a 2026 study. Working with virus-like particles that copy and transcribe but cannot fully infect, plus microscopy, drug tests, and acidity probes, they tracked exit routes. How much virus leaves, and in what state, shapes how harmful an infection becomes.
Infected cells pushed lysosomes to fuse with the surface more often, and that route carried most virus out, ahead of the standard secretion path. The viral ORF3a protein drove the fusion boost, while ORF3a and the E protein lowered lysosome acidity and enzyme power, shielding new virus from early damage. Making sacs less acidic with a drug raised release further.
Catalog record
| CREATOR | Fujun Qin, Chuang Yan, Zizheng Liu, Dianbing Wang, Huimin Zhong, Qiang Ding, Minghai Chen, Xian‐En Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61630 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |