Progerin-induced nuclear envelope remodeling is shaped by cell division and NUP153
Ayse Mubine Turkmen, Jing Wang, Adam Frost, Katharine S Ullman · 2026
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Description
Ayse Mubine Turkmen and co-authors trace how progerin warps the nuclear envelope in two stages in a 2026 study. Progerin, the faulty lamin behind Hutchinson-Gilford progeria syndrome, builds up in the membrane around the nucleus. Using cells where progerin could be switched on, they watched the damage unfold.
Before division, progerin hit mainly the inner membrane, causing local swelling, folds, and stacked membrane pockets rich in the pore protein NUP153, while the outer membrane stayed near normal. After division and reassembly, nuclei turned strongly lobed, the classic disease shape. Removing NUP153 cut the early pocket formation, suggesting it helps start the folding, with lessons for aging cells that divide or rest.
Catalog record
| CREATOR | Ayse Mubine Turkmen, Jing Wang, Adam Frost, Katharine S Ullman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46091 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |