The roles of the acetyltransferase domains of the chromatin regulators KAT6A and KAT6B in vivo
Tim Thomas, Shezlie Malelang, Yuqing Yang, Maria I. Bergamasco, Andrew J. Kueh, Alexandra L. Garnham, Nishika Ranathunga, Gordon K. Smyth, Anne K. Voss · 2026
Read The roles of the acetyltransferase domains of the chromatin regulators KAT6A and KAT6B in vivo by Tim Thomas, Shezlie Malelang, Yuqing Yang, Maria I. Bergamasco, Andrew J. Kueh, Alexandra L. Garnham, Nishika Ranathunga, Gordon K. Smyth, Anne K. Voss (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13327545.txt.
Description
Tim Thomas and colleagues test what gene-regulating enzymes actually do in mouse embryos in a 2026 study. KAT6A and KAT6B add acetyl marks to histones and overlap heavily during development, and losing KAT6A causes bone pattern shifts, heart defects, and failure to form blood stem cells. The team asked whether the marking action itself explains those effects.
Mice whose enzymes kept their shape but lost marking power fared better than mice missing KAT6A outright. Mutants still showed heart wall defects and weaker blood stem cell activity, but bone pattern and the aortic arch formed normally, and hitting both enzymes worsened matters only partly. The proteins thus do work beyond their chemical marking role.
Catalog record
| CREATOR | Tim Thomas, Shezlie Malelang, Yuqing Yang, Maria I. Bergamasco, Andrew J. Kueh, Alexandra L. Garnham, Nishika Ranathunga, Gordon K. Smyth, Anne K. Voss |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65139 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |