The notochord: development, disease and stem cell-based modelling
Julie Warin, Tiago Rito, James Briscoe, Guillaume Blin, Anne Camus · 2026
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Description
Julie Warin and co-authors review the notochord, the rod that defines backboned animals, in a 2026 article. The structure supports the early embryo and sends signals to nearby tissues, and in mammals its cells persist inside spinal discs as the soft nucleus pulposus. The authors gather what is known from development through disc formation.
They trace the signals that set aside axial tissue and commit cells to the notochord line. That knowledge then guides stem cell models, including flat patterns and 3D organoids in mouse and human work. Such models open ways to study disorders from faulty notochord function and the disc wear of later life. Open questions close the review.
Catalog record
| CREATOR | Julie Warin, Tiago Rito, James Briscoe, Guillaume Blin, Anne Camus |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84262 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |