Effective Management of Recurrent Conjunctival Intraepithelial Neoplasia Using Topical Mitomycin C 0.02%
Haya A Alnafisah, Mutlaq H Alshaibani, Mona I AlOmairini · 2026
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Description
Haya A. Alnafisah and colleagues report topical treatment of recurrent conjunctival intraepithelial neoplasia. Their 2026 case paper follows a 64-year-old man with a recurrent mass in the right eye causing irritation, a decade after excision of a similar lesion there. Examination found a 6 by 7 mm raised, gelatinous lesion on the nasal conjunctiva, extending from the caruncle to the limbus with about 2 mm of corneal involvement.
Rather than repeat surgery, the team treated the lesion with topical mitomycin C 0.02% in a cyclic regimen. Marked regression appeared after four weeks, and a second course for a small residual lesion achieved complete regression with mild scarring. Treatment was well tolerated, with only mild transient discomfort, injection, and tearing, and no recurrence over more than one year of follow-up. The authors present topical mitomycin as an effective conservative option for selected recurrent cases, pending larger studies.
Catalog record
| CREATOR | Haya A Alnafisah, Mutlaq H Alshaibani, Mona I AlOmairini |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 14 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |