Metformin Use Is Associated With Reduced Inflammation and Pain After Total Knee Arthroplasty in Patients With Type 2 Diabetes
Zhongyu Luo, Xiaoying Zhong, Chen Zhang, Mingwei Hu, Muyang Yu, Bin Feng, Xisheng Weng · 2026
Read Metformin Use Is Associated With Reduced Inflammation and Pain After Total Knee Arthroplasty in Patients With Type 2 Diabetes by Zhongyu Luo, Xiaoying Zhong, Chen Zhang, Mingwei Hu, Muyang Yu, Bin Feng, Xisheng Weng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13327049.txt.
Description
Zhongyu Luo and team tested if steady metformin use eases swelling and pain after full knee replacement in people with type 2 diabetes. Their 2026 single-site look-back study took in first-time knee replacement patients from December 2024 to May 2025, sorted by steady metformin use. Matched pairs gave sixty pairs to compare. Swelling and pain after surgery still block healing. Metformin's anti-swelling traits made its effect worth testing.
Metformin users had lower C-reactive protein and lower interleukin-6 on days one and three after surgery. They had lower red-cell sedimentation rate on day three, and lower day-three pain scores than non-users. The gaps held after change for factors. The team holds that steady metformin use tracks with less swelling and pain after surgery in diabetic knee patients. They put the widely used drug forward as a cheap add-on for early healing.
Catalog record
| CREATOR | Zhongyu Luo, Xiaoying Zhong, Chen Zhang, Mingwei Hu, Muyang Yu, Bin Feng, Xisheng Weng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |