Concomitant activation of D1 dopamine and α2A adrenergic receptors improves cognition better than methylphenidate in two rodent behavioral tests
Luke Bransom, Ava P Bassett, Mi Zhou, Richard B Mailman, Yang Yang · 2026
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Description
Luke Bransom and colleagues compare drug pairs against methylphenidate for cognition in rats in a 2026 study. The standard ADHD drug lifts dopamine and norepinephrine broadly, with uneven benefit between patients.
Animals took methylphenidate, a D1 dopamine agonist, the alpha2A agonist guanfacine, cannabigerol, or paired agents. Tasks measured order memory, flexibility, and spatial working memory. Pairing a D1 agonist with an alpha2A agonist beat methylphenidate, but only in rats that started with poor scores. Strong starters gained nothing extra. The authors suggest tailored receptor pairs deserve study for people with clear cognitive deficits rather than as a blanket swap.
Catalog record
| CREATOR | Luke Bransom, Ava P Bassett, Mi Zhou, Richard B Mailman, Yang Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45331 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |