Tranexamic acid inhibits mitochondrial DNA release and reduces inflammatory response in an in vitro model of OGD/R-induced Caco-2 cell injury
Ziyue Wang, Liman Huo, Hong Liu, Shuwei Shi, Rui Feng · 2026
Read Tranexamic acid inhibits mitochondrial DNA release and reduces inflammatory response in an in vitro model of OGD/R-induced Caco-2 cell injury by Ziyue Wang, Liman Huo, Hong Liu, Shuwei Shi, Rui Feng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13326343.txt.
Description
Ziyue Wang and team studied how tranexamic acid protects the gut lining after ischemia-reperfusion injury. Their 2026 study notes that intestinal blood-return damage remains a hard clinical problem with no sure treatment. Tranexamic acid, a clot-saving drug used in bleeding, had earlier shown barrier protection by an unclear mechanism. The team built an oxygen-glucose loss and reperfusion model in Caco-2 gut cells to probe the cause.
It reversed the injury's effects on barrier function, restoring cell-layer electric resistance and reducing FITC-dextran leakiness across cell layers, with microscopy supporting the result. It also boosted mitochondrial membrane charge, suppressed release of cell-power DNA, and eased immune responses. It guards the gut barrier through cell-power defense and reduced swelling, suggesting therapeutic promise for intestinal blood-return injury.
Catalog record
| CREATOR | Ziyue Wang, Liman Huo, Hong Liu, Shuwei Shi, Rui Feng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |