Cyclosporine A promotes renal fibrosis through activating endoplasmic reticulum stress by targeting miR-212-5p/ATF6 axis
Juan Wang, Zheng Li, Bei Qing, Zhenkun Xia, Yunchang Yuan, Lei Zhang, Zhiwen Liu · 2026
Read Cyclosporine A promotes renal fibrosis through activating endoplasmic reticulum stress by targeting miR-212-5p/ATF6 axis by Juan Wang, Zheng Li, Bei Qing, Zhenkun Xia, Yunchang Yuan, Lei Zhang, Zhiwen Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13326304.txt.
Description
Juan Wang and co-authors trace how a transplant drug scars the kidneys it is meant to protect, in a 2026 study. Cyclosporine A suppresses the immune system and is widely used after transplants. Long use, though, breeds renal fibrosis, a stiffening scar that erodes kidney function. The molecular chain behind that harm was murky.
In mice and in cultured kidney tubule cells, the drug switched on stress inside the cell's protein-folding workshop. Collagen and scar markers climbed in step. A small regulatory RNA rose sharply in treated kidneys, mostly in the tubules. Blocking that pathway with a stress-relieving compound tested the chain of cause. The work points to the RNA and its stress partner as drug targets.
Catalog record
| CREATOR | Juan Wang, Zheng Li, Bei Qing, Zhenkun Xia, Yunchang Yuan, Lei Zhang, Zhiwen Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |