Comparison of the anti-inflammatory effects of esomeprazole and fexuprazan in lipopolysaccharide-stimulated RAW 264.7 macrophages
Gi-Beom Ju, Seong Jun Kim, Daye Lee, Min Je Kim, Wan-Kyu Ko, Min Jai Cho, Seil Sohn · 2026
Read Comparison of the anti-inflammatory effects of esomeprazole and fexuprazan in lipopolysaccharide-stimulated RAW 264.7 macrophages by Gi-Beom Ju, Seong Jun Kim, Daye Lee, Min Je Kim, Wan-Kyu Ko, Min Jai Cho, Seil Sohn (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13326150.txt.
Description
Gi-Beom Ju and co-authors compare two acid drugs for calming inflamed immune cells, hunting a bonus use beyond the stomach, in a 2026 study. Mouse macrophages were provoked with a bacterial toxin, then dosed with esomeprazole or the newer fexuprazan. The team measured nitric oxide, inflammatory messengers, a potassium channel tied to inflammation, and the switching of a key signaling pathway.
Both drugs cut the inflammatory output and dimmed the pathway. Fexuprazan hit harder almost everywhere: stronger suppression of messengers and the channel, and it nudged the cells toward a calmer state the other drug did not reach. The authors suggest the newer drug carries the greater anti-inflammatory promise of the pair.
Catalog record
| CREATOR | Gi-Beom Ju, Seong Jun Kim, Daye Lee, Min Je Kim, Wan-Kyu Ko, Min Jai Cho, Seil Sohn |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |