Venetoclax and hypomethylating agents synergize to increase cell death and metabolic remodeling in acute B-lymphoblastic leukemia cells
Patricia Maass, Sandra Lange, Felix Wittig, Nares Trakooljul, Frieder Hadlich, Anett Sekora, Christian Schmidt, Hugo Murua Escobar, Klaus Wimmers, Burkhard Hinz, Christian Junghanss, Anna Richter · 2026
Read Venetoclax and hypomethylating agents synergize to increase cell death and metabolic remodeling in acute B-lymphoblastic leukemia cells by Patricia Maass, Sandra Lange, Felix Wittig, Nares Trakooljul, Frieder Hadlich, Anett Sekora, Christian Schmidt, Hugo Murua Escobar, Klaus Wimmers, Burkhard Hinz, Christian Junghanss, Anna Richter (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13326043.txt.
Description
Patricia Maass and colleagues pair venetoclax with drugs that lower methylation against B-cell leukemia in a 2026 study. The duo already works in myeloid leukemia. Its value in acute lymphoblastic leukemia was untested.
Four cell lines got venetoclax, azacytidine, or decitabine alone and in pairs. The pairs cut cell activity far more than single drugs. Single-cell scans of a treated patient-derived model showed venetoclax jamming both energy routes. Cells lost both oxygen-based burning and glycolysis. Adding a partner drug deepened the energy crash. Decitabine helped most, with lower breathing and ATP output. No joint effect showed on methylation itself. The synergy runs through cell energy.
Catalog record
| CREATOR | Patricia Maass, Sandra Lange, Felix Wittig, Nares Trakooljul, Frieder Hadlich, Anett Sekora, Christian Schmidt, Hugo Murua Escobar, Klaus Wimmers, Burkhard Hinz, Christian Junghanss, Anna Richter |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58563 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |