A novel EGR1-driven GLUL/mTOR axis regulates macropinocytosis-mediated crosstalk in pancreatic stellate cell-cancer metastasis
Ran Xue, Jun Zhou, Yawei Liu, Yuxi Liu, Jing Wu, Xinran Song · 2026
Read A novel EGR1-driven GLUL/mTOR axis regulates macropinocytosis-mediated crosstalk in pancreatic stellate cell-cancer metastasis by Ran Xue, Jun Zhou, Yawei Liu, Yuxi Liu, Jing Wu, Xinran Song (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13325598.txt.
Description
Ran Xue and co-authors trace a gene circuit in support cells that slows pancreatic cancer spread in a 2026 study. Liver spread depends on chatter between pancreatic stellate cells and cancer cells, including how cancer cells gulp nutrients.
Single-cell sequencing of human tumor tissue flagged the factor EGR1 as rich in stellate cells. Bench tests showed EGR1 switches on GLUL, which fires mTOR signaling and calms stellate cell activation. Cancer cells beside such stellate cells took up fewer nutrients through macropinocytosis, made less energy, and moved less. In mice, the circuit cut liver spread. The pathway offers a fresh target for breaking support cell help.
Catalog record
| CREATOR | Ran Xue, Jun Zhou, Yawei Liu, Yuxi Liu, Jing Wu, Xinran Song |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66651 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |