Quercetin Delivered by Mesenchymal Stem Cell-Derived Exosomes Improves Liver Fibrosis via the PI3K/Akt Signaling Pathway
Dan Fang, Jing Zhang, Qingqing Zhao, Yuting Fan, Xiaojin Lin, Dan Liang, Lianjun Zhong, Yingchun Zhang, Simeng Yan, Tao Shen, Yingkun Meng, Xing Zhao, Shi Zuo · 2026
Read Quercetin Delivered by Mesenchymal Stem Cell-Derived Exosomes Improves Liver Fibrosis via the PI3K/Akt Signaling Pathway by Dan Fang, Jing Zhang, Qingqing Zhao, Yuting Fan, Xiaojin Lin, Dan Liang, Lianjun Zhong, Yingchun Zhang, Simeng Yan, Tao Shen, Yingkun Meng, Xing Zhao, Shi Zuo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13325349.txt.
Description
Dan Fang and colleagues load the plant compound quercetin into stem cell exosomes to treat liver fibrosis in a 2026 study. Quercetin fights scarring but dissolves poorly, so little of a dose reaches the liver.
Exosomes from human umbilical cord stem cells carried the drug in a mouse model of toxin-driven fibrosis. The loaded vesicles eased scarring more than free quercetin at the same dose, and cell tests showed stronger calming of scar-forming stellate cells. Release lasted up to 48 hours, and the vesicles stayed stable for at least a week. Network analysis and bench checks tied the gain to deeper blocking of the PI3K and Akt pathway.
Catalog record
| CREATOR | Dan Fang, Jing Zhang, Qingqing Zhao, Yuting Fan, Xiaojin Lin, Dan Liang, Lianjun Zhong, Yingchun Zhang, Simeng Yan, Tao Shen, Yingkun Meng, Xing Zhao, Shi Zuo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33693 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |