Efficient Synthesis of Novel Propargyl Sulfamate Derivatives and Their Potent Inhibitory Effects on Human Carbonic Anhydrase Isoenzymes
Ufuk Atmaca, Songül Bayrak, Cetin Bayrak · 2026
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Description
Ufuk Atmaca, Songül Bayrak, and Cetin Bayrak synthesize 21 new propargyl sulfamate compounds as enzyme blockers in a 2026 chemistry study. The targets are human carbonic anhydrases, enzymes tied to glaucoma, altitude sickness, and tumor growth.
A practical route reacted propargyl alcohols with chlorosulfonyl isocyanate to build the set. All compounds blocked enzymes I and II at nanomolar levels, with IC50 values as low as 8.97 nM for the first enzyme. The star compound, labeled 2i, beat the standard drug acetazolamide by 7.72 fold on enzyme I and 15.35 fold on enzyme II. It also led against the tumor-linked enzymes IX and XII.
Catalog record
| CREATOR | Ufuk Atmaca, Songül Bayrak, Cetin Bayrak |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42746 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |