Broad-Spectrum Antimicrobial Activity of a Ruthenium(II) Polypyridyl Complex against Multidrug-Resistant Uropathogens and Biofilms
Beth James, Simon D Fairbanks, Mia Horton, Jim A Thomas, Samantha McLean, Adam M Varney · 2026
Read Broad-Spectrum Antimicrobial Activity of a Ruthenium(II) Polypyridyl Complex against Multidrug-Resistant Uropathogens and Biofilms by Beth James, Simon D Fairbanks, Mia Horton, Jim A Thomas, Samantha McLean, Adam M Varney (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13325168.txt.
Description
Beth James and co-authors evaluate a ruthenium compound against drug-resistant urinary germs and their biofilms in a 2026 study. Catheter infections persist because biofilms shield bacteria from most antibiotics.
The compound, KLS-116, killed diverse resistant species at doses at or below 25 micromolar in lab tests. Mixed with standard antibiotics it never clashed, giving neutral or additive effects. In flow models of catheters it shrank mature biofilms, and in still models it cleared them fully at 16 times the base dose within a day. Over 42 days of exposure, bacteria barely shifted in sensitivity, unlike rapid ciprofloxacin resistance. Acid levels did sway its strength.
Catalog record
| CREATOR | Beth James, Simon D Fairbanks, Mia Horton, Jim A Thomas, Samantha McLean, Adam M Varney |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41731 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |