3D chromatin architecture in cancer: mechanisms of dysregulation and emerging therapeutic strategies
Sunyoung Jang, Kyung Hyun Yoo · 2026
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Description
Sunyoung Jang and Kyung Hyun Yoo review how the folding of the genome goes awry in cancer. Their 2026 paper explains that spatial architecture runs gene use, guards genome health, and sets each cell type's own gene reading. In tumors, this folding breaks down through altered control parts, faulty building proteins such as CTCF and cohesin, faulty chromatin looping, and rework of topologically associating domains.
Such breakage can switch on cancer-driving switches, forge inappropriate promoter-enhancer contacts, and reprogram DNA packing on a large scale to sustain malignant states. High-resolution tools including Hi-C, HiChIP, and single-cell 3D genomics have exposed widespread spatial reorganization across tumor types, revealing progression mechanisms invisible to linear mutation analysis alone. The review evaluates emerging therapies aimed at genome folding, from epigenetic modulators to switch breakage and phase-separation-based interventions.
Catalog record
| CREATOR | Sunyoung Jang, Kyung Hyun Yoo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |