Yes-Associated Protein Drives Helicobacter pylori–Induced Metaplastic Changes in Gastric Epithelium
Byeong Min Yu, So Dam Lee, Bo Ram Hwang, Haengdueng Jeong, Jiseon Kim, Seokyoung Hwang, Minsoo Noh, Ki Taek Nam, Yong Chan Lee · 2026
Read Yes-Associated Protein Drives Helicobacter pylori–Induced Metaplastic Changes in Gastric Epithelium by Byeong Min Yu, So Dam Lee, Bo Ram Hwang, Haengdueng Jeong, Jiseon Kim, Seokyoung Hwang, Minsoo Noh, Ki Taek Nam, Yong Chan Lee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13324660.txt.
Description
Byeong Min Yu and eight co-authors trace a driver of stomach lining change in a 2026 study. Infection with Helicobacter pylori can push the stomach lining toward a precancerous state called metaplasia. The team found that a bacterial toxin switches on a protein named Yes-associated protein, which then reprograms the lining cells.
Working with human tissue, cell lines, and mice, they showed the protein's rise depends on a partner that shields it from disposal. Turning the protein up or down in the stomach's chief cells turned the metaplastic markers up or down with it, including loss of acid-making cells and a wider growth zone. Drugs that block the protein cut the signal. The authors name it a treatment target.
Catalog record
| CREATOR | Byeong Min Yu, So Dam Lee, Bo Ram Hwang, Haengdueng Jeong, Jiseon Kim, Seokyoung Hwang, Minsoo Noh, Ki Taek Nam, Yong Chan Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |