Leptin Signaling at the Crossroads of Obesity, Immunity, and Cancer: Mechanistic Insights and Therapeutic Implications
Gitima Deka, Pil-Hoon Park · 2026
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Description
Gitima Deka and Pil-Hoon Park review leptin at the meeting point of obesity, immunity, and cancer in a 2026 article. Leptin is a hormone from fat tissue that controls appetite and energy use, and blood levels run high in obesity.
Fresh evidence shows leptin acts on immune cells inside tumors and can wear them down, blunting the attack on cancer. It also rewires how both immune and cancer cells burn fuel, which may fuel growth. The picture is not one-sided, since leptin can boost immunity in some settings. The authors weigh pairing leptin-targeted drugs with immunotherapy. Their account frames leptin as one link between extra body fat and weaker cancer control.
Catalog record
| CREATOR | Gitima Deka, Pil-Hoon Park |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83022 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |