Early NGF–TrkA–CGRP signaling-related changes in dorsal root ganglia are associated with mechanical hypersensitivity in a zymosan A-induced SKG model prior to overt arthritis
Yumi Kawata, Hiroshi Funakoshi · 2026
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Description
Yumi Kawata and Hiroshi Funakoshi probe early pain signals before arthritis appears in a 2026 mouse study. Pain in axial spondyloarthritis can start before joint swelling shows or linger after inflammation settles, and its early drivers are unclear.
Female SKG mice got zymosan A, with some also given a preventive antibody against nerve growth factor. By day 10 the treated mice showed touch sensitivity but no rise in arthritis scores. In dorsal root ganglia, pain-linked CGRP neurons shifted toward larger sizes and TrkA signaling changed. Blocking nerve growth factor softened both the sensitivity and the nerve changes. The work links early pain to nerve sensitization and supports study of anti-NGF care.
Catalog record
| CREATOR | Yumi Kawata, Hiroshi Funakoshi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25734 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |