Multiomics Reveals NDRG1-Driven Oral Squamous Cell Carcinoma Progression: Competitive Endogenous RNAs Regulation and Proangiogenic Microenvironment Remodelling
Lei Feng, Yi Ou, Linqing Tian, Wenjie Jiang, Min Zhang, Xun Sheng · 2026
Read Multiomics Reveals NDRG1-Driven Oral Squamous Cell Carcinoma Progression: Competitive Endogenous RNAs Regulation and Proangiogenic Microenvironment Remodelling by Lei Feng, Yi Ou, Linqing Tian, Wenjie Jiang, Min Zhang, Xun Sheng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13324454.txt.
Description
Lei Feng and co-authors trace how the gene NDRG1 drives oral squamous cell carcinoma growth in a 2026 multiomics study. This cancer of the mouth is highly aggressive, and the forces behind its spread remain partly unclear.
The team combined bulk, single-cell, and spatial gene data with lab and animal tests. A regulatory chain, MSTRG.47889 with miR-1299 and NDRG1, sped tumor growth and invasion while weakening cell adhesion. Cells high in NDRG1 grew in tumors, shifted toward a partial transition state, and sat in low-oxygen niches. Those zones may work with vessel cells through ANGPTL4 and CDH5 signals. NDRG1 stands out as a possible target for diagnosis and treatment.
Catalog record
| CREATOR | Lei Feng, Yi Ou, Linqing Tian, Wenjie Jiang, Min Zhang, Xun Sheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42182 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |