Lupus nephritis and kidney transplantation: A narrative review of patient and graft outcomes
Tabassum Elahi, Saima Ahmed, Muhammed Mubarak · 2026
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Description
Tabassum Elahi, Saima Ahmed, and Muhammed Mubarak review kidney transplant for lupus nephritis, a severe complication of systemic lupus erythematosus. Their 2026 narrative review notes that despite better immunosuppressive therapy, many patients progress to end-stage kidney disease, for which transplant remains the treatment of choice. Yet the survival advantage of transplant only in lupus-related kidney failure is not yet clearly defined.
The review pulls together guidelines and recent evidence on timing and care, weighing the standard advice to achieve disease quiescence before transplant against emerging support for preemptive transplant and individualized immune drugs. New drugs such as voclosporin and belimumab, plus biomarkers including urinary monocyte chemoattractant protein-1, matrix metalloproteinase-7, and B-cell activating factor, show promise for selecting patients, tracking activity, and predicting recurrence. The authors call for refined strategies to optimize both patient and graft outcomes.
Catalog record
| CREATOR | Tabassum Elahi, Saima Ahmed, Muhammed Mubarak |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |