m6A-modified Mid1 promotes sevoflurane-induced cognitive impairment in neonatal mice by ubiquitin-mediated degradation of Syngap1
Jian-Jun Shen, Ying-Jie Yang, Ying-Ying Tang, Shuo Yan, Mei-dan Ying, Wen-Hu Chen, Li-Li Xu · 2026
Read m6A-modified Mid1 promotes sevoflurane-induced cognitive impairment in neonatal mice by ubiquitin-mediated degradation of Syngap1 by Jian-Jun Shen, Ying-Jie Yang, Ying-Ying Tang, Shuo Yan, Mei-dan Ying, Wen-Hu Chen, Li-Li Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13324386.txt.
Description
Jian-Jun Shen and team mapped a chain linking the anesthetic sevoflurane to learning problems in newborn mice. Their 2026 study combined RNA methylation sequencing, gene profiling, learning tests, and lab assays, motivated by concern that early exposure to the drug may carry lasting effects on the growing brain. The focus was m6A RNA change and ubiquitin-dependent protein control involving Mid1 and Syngap1.
Analysis found 2,091 changed m6A sites. Mechanistically, Mid1 drove degradation of Syngap1 through the cell's waste pathway, and suppressing Mid1 eased learning and memory deficits while improving neuronal survival and dampening apoptotic signals. The m6A eraser ALKBH5 and reader YTHDF2 jointly tuned Mid1 messenger RNA stability, and pathway analysis tied the Mid1-Syngap1 axis to MAPK signaling disruption. The authors propose this circuit as a target for brain-protecting plans against anesthesia-related harm in children.
Catalog record
| CREATOR | Jian-Jun Shen, Ying-Jie Yang, Ying-Ying Tang, Shuo Yan, Mei-dan Ying, Wen-Hu Chen, Li-Li Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |