Disturbed metabolic adaptation drives natural killer cell dysfunction in association with nosocomial infection during human sepsis
André van der Wurff, Monika Gambusz, Bettina Budeus, Maren Claus, Carsten Watzl, Dani Miteva, Brendon P Scicluna, Ignacio Rubio, Elena Siakaeva, Frederic Zinsmeister, Sonja Vonderhagen, Nadja Klenke, Frank Herbstreit, Karsten Schmidt, Marc M Berger, Thorsten Brenner, Marcel Dudda, Stefanie B Flohé · 2026
Read Disturbed metabolic adaptation drives natural killer cell dysfunction in association with nosocomial infection during human sepsis by André van der Wurff, Monika Gambusz, Bettina Budeus, Maren Claus, Carsten Watzl, Dani Miteva, Brendon P Scicluna, Ignacio Rubio, Elena Siakaeva, Frederic Zinsmeister, Sonja Vonderhagen, Nadja Klenke, Frank Herbstreit, Karsten Schmidt, Marc M Berger, Thorsten Brenner, Marcel Dudda, Stefanie B Flohé (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13324300.txt.
Description
André van der Wurff leads a longitudinal study of natural killer cell failure in human sepsis, published in 2026. Sepsis patients catch new infections easily while in hospital. Killer cells should release interferon gamma to clear invading bacteria. Interleukin 12 and nutrient uptake boost that response.
Blood killer cells taken during sepsis showed suppressed receptor levels for interleukin 12. Their interferon output after exposure to Staphylococcus aureus also fell. The fault lasted at least fourteen days and ran worst in patients who later caught secondary infections. It sat inside the cells rather than in their surroundings. Stalled fuel sensing through the mTORC1 hub was the linked mechanism.
Catalog record
| CREATOR | André van der Wurff, Monika Gambusz, Bettina Budeus, Maren Claus, Carsten Watzl, Dani Miteva, Brendon P Scicluna, Ignacio Rubio, Elena Siakaeva, Frederic Zinsmeister, Sonja Vonderhagen, Nadja Klenke, Frank Herbstreit, Karsten Schmidt, Marc M Berger, Thorsten Brenner, Marcel Dudda, Stefanie B Flohé |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64951 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |