RNA helicase DHX29 controls the translation of transcription factors involved in germinal center response and plasma cell differentiation in mice
Jiayi Zhao, Xiaoyu He, Peicheng Hong, Lianghua Lin, Ying Du, Pengda Chen, Lixiao Zhang, Jiale Leng, Lihui Ma, Jun Xie, Xinyong Lin, Abidan Adilijiang, Jiazhen Wang, Yazhen Hong, Zhengtao Xiao, Wen-Hsien Liu, Changchun Xiao · 2026
Read RNA helicase DHX29 controls the translation of transcription factors involved in germinal center response and plasma cell differentiation in mice by Jiayi Zhao, Xiaoyu He, Peicheng Hong, Lianghua Lin, Ying Du, Pengda Chen, Lixiao Zhang, Jiale Leng, Lihui Ma, Jun Xie, Xinyong Lin, Abidan Adilijiang, Jiazhen Wang, Yazhen Hong, Zhengtao Xiao, Wen-Hsien Liu, Changchun Xiao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13324185.txt.
Description
Jiayi Zhao and team found the RNA helicase DHX29 as a critical regulator of antibody output in mice. Their 2026 study began with a CRISPR screen of RNA helicases in a laboratory system of plasma cell differentiation, then tested mice lacking Dhx29 only in B cells. Protein-making control, the regulation of which message RNAs get turned into protein, is still not fully known in immunity, and DHX29 emerged as a strong candidate.
Mice without B-cell DHX29 showed severely impaired germinal center formation, plasma cell change, and antibody output. Mechanistically, DHX29 promotes translation of the transcription factors Tcf3 and Tle3 by binding their message RNA untranslated regions. Without it, B cells proliferated normally but failed to switch to IgG1 or become plasma cells, and restoring TCF3 and TLE3 largely rescued the change. The work highlights protein-making control as a lever on immune responses.
Catalog record
| CREATOR | Jiayi Zhao, Xiaoyu He, Peicheng Hong, Lianghua Lin, Ying Du, Pengda Chen, Lixiao Zhang, Jiale Leng, Lihui Ma, Jun Xie, Xinyong Lin, Abidan Adilijiang, Jiazhen Wang, Yazhen Hong, Zhengtao Xiao, Wen-Hsien Liu, Changchun Xiao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 89 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |