Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer’s disease progression
Pooja Jadiya, Elena Berezhnaya, Devin W Kolmetzky, Dhanendra Tomar, Henry M Cohen, Shatakshi Shukla, Manfred Thomas, Salman Khaledi, Joanne F Garbincius, Liam Kennedy, Oniel Salik, Darpan Raghav, Alycia N Hildebrand, John W Elrod · 2026
Read Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer’s disease progression by Pooja Jadiya, Elena Berezhnaya, Devin W Kolmetzky, Dhanendra Tomar, Henry M Cohen, Shatakshi Shukla, Manfred Thomas, Salman Khaledi, Joanne F Garbincius, Liam Kennedy, Oniel Salik, Darpan Raghav, Alycia N Hildebrand, John W Elrod (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13324160.txt.
Description
Pooja Jadiya and team tested whether blocking calcium uptake in neurons can slow Alzheimer disease. Their 2026 study used genetic mouse models to delete the mitochondrial calcium uniporter channel in neurons of 3xTg-AD mice, a robust Alzheimer model. It probed a mechanism in which lost calcium efflux drives calcium overload in cells. Cell lab work with Mcu knockdown backed the animal work.
Losing calcium uptake in neurons reduced amyloid beta and tau pathology, synapse trouble, and cognitive decline in the mice. In cells, knockdown lowered matrix calcium, redox imbalance, and cell dysfunction, while restoring cell cleanup and protecting neurons against amyloid toxicity and death. Imaging confirmed improved structure in the treated mice. The authors propose blocking calcium uptake in neurons as a powerful therapeutic target for impeding disease progression.
Catalog record
| CREATOR | Pooja Jadiya, Elena Berezhnaya, Devin W Kolmetzky, Dhanendra Tomar, Henry M Cohen, Shatakshi Shukla, Manfred Thomas, Salman Khaledi, Joanne F Garbincius, Liam Kennedy, Oniel Salik, Darpan Raghav, Alycia N Hildebrand, John W Elrod |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 99 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |